The video card is questionable. You'll most likely have to stick to lower resolutions and mostly low settings. The minimum card required is the GeForce 6800GT or the Radeon X800. If we consult the handy video card hierarchy chart here
http://www.tomshardware.com/reviews/best-graphics-card-game-performance-radeon-hd-6670,2935-7.html

We can see that the Radeon 5450 falls in at a tier below the 6800 and X800. So it would stand to reason that your Fallout 3 experience will be less than great.

I don't know what they guy who says you'll be able to run the game at med/high settings is smoking. Obviously if your video card doesn't meet the minimum specs, that will not be the case.

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